CASI Pharmeceuticals

ENMD-2076

ENMD-2076 has shown promising activity in a completed Phase 1 clinical trial in various types of solid tumors including ovarian, breast, liver, renal and sarcoma, as well as in leukemia, and multiple myeloma, and has also completed a Phase 2 clinical trial in advanced ovarian cancer.

ENMD-2076

We are currently conducting multiple Phase 2 studies of ENMD-2076 in FLC, triple-negative breast cancer (TNBC), advanced/metastatic soft tissue sarcoma (STS), and advanced ovarian clear cell carcinomas (OCCC).

Our TNBC trial has expanded to include sites in China and is currently enrolling patients. CFDA also approved our clinical trial applications for both a Phase 2 trial of ENMD-2076 for ovarian clear cell carcinoma (OCCC) as well as for advanced/metastatic soft tissue sarcoma (STS).

ENMD-2076 has received orphan drug designation from the U.S. FDA for the treatment of ovarian cancer, multiple myeloma, acute myeloid leukemia and hepatocellular carcinoma (HCC) and received EU orphan drug designation for the treatment of hepatocellular carcinoma including fibrolamellar carcinomas (FLC)

ENMD-2076 has strong global intellectual property protection worldwide with patents approved or pending for approvals in the U.S., Canada, Japan and many other countries. On May 6, 2013, the Chinese State Intellectual Property Office issued a patent for ENMD-2076 covering composition of matter and uses to treat various cancers.

About Us

A leading US-headquartered, NASDAQ-listed, biopharmaceutical company targeting the global market, with a focus on China.

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In the News

CASI's turnaround turns eastward; firm seeks to be Celgene of China

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Poster

Antitumor activity, safety and predictive biomarker results of ENMD-2076 administered to patients with recurrent ovarian clear cell carcinoma (OCCC): A trial of the Princess Margaret Phase II Consortium

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Poster

Senescence as a Mechanism of Resistance to Aurora Kinase Inhibition with ENMD-2076 in p53 mutated Triple-Negative Breast Cancer (TNBC) Models

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