2ME2 (2-methoxyestradiol) is an orally active compound that has antiproliferative, antiangiogenic and anti-inflammatory properties. The inhibition of angiogenesis is an important approach to the treatment of both cancer and autoimmune diseases such as rheumatoid arthritis. 2ME2 has potential as a single agent in rheumatoid arthritis based on its antiangiogenic, anti-inflammatory, and anti-osteoclastic (bone resorption) properties.
2ME2 has also demonstrated positive preclinical results for multiple sclerosis.
The U.S. Patent & Trademark Office issued on March 19, 2013 patent #8,399,440—“Disease Modifying Anti-Arthritic Activity of 2-Methoxyestradiolfor composition and method claims covering the combination of 2ME2 and methotrexate for the treatment of rheumatic diseases, including rheumatoid arthritis”.